西酞普兰过量继发癫痫发作。

Seizure secondary to citalopram overdose.

作者信息

Cuenca Peter John, Holt Kurtis Rex, Hoefle Jeffrey David

机构信息

Madigan-University of Washington Emergency Medicine Residency, Madigan Army Medical Center, Fort Lewis, Washington 98433, USA.

出版信息

J Emerg Med. 2004 Feb;26(2):177-81. doi: 10.1016/j.jemermed.2003.06.005.

DOI:10.1016/j.jemermed.2003.06.005

PMID:14980340

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are widely used in the community for treating many forms of mental illness. Citalopram, a newer generation SSRI, is commonly prescribed but, despite its low toxicity profile, has a danger of seizure and dysrhythmias in overdose. This case report documents the key aspects in treatment of a citalopram overdose resulting in a seizure and an episode of supraventricular tachycardia (SVT). The seizure was successfully treated with benzodiazepines. The SVT was terminated with administration of adenosine. We review the literature and make recommendations on treatment of citalopram overdose.

摘要

选择性5-羟色胺再摄取抑制剂（SSRIs）在临床上被广泛用于治疗多种精神疾病。西酞普兰作为新一代的SSRI，是常用的处方药，尽管其毒性较低，但过量服用时有癫痫发作和心律失常的风险。本病例报告记录了西酞普兰过量服用导致癫痫发作和室上性心动过速（SVT）发作的治疗关键环节。癫痫发作通过苯二氮䓬类药物成功控制。SVT通过静脉注射腺苷终止发作。我们回顾了相关文献并对西酞普兰过量服用的治疗提出了建议。