Catalano G, Catalano M C, Hanley P F
Department of Psychiatry, University of South Florida College of Medicine, Tampa 33613, USA.
Clin Neuropharmacol. 1998 Nov-Dec;21(6):347-50.
Buspirone is a novel anxiolytic agent that is commonly used in the treatment of generalized anxiety disorder. Many studies have found it to be equal in efficacy to the benzodiazepines in the treatment of this illness. Its use has gained favor over the past few years because of its relatively mild and tolerable side-effect profile. The authors report a case of buspirone overdose that resulted in a generalized tonic clonic seizure approximately 36 hours after ingestion. Although there have been no previous cases of seizure induction by buspirone in humans, there are animal models of this phenomenon. The authors describe the case, review the literature regarding buspirone overdose and toxicity, and discuss treatment recommendations.
丁螺环酮是一种新型抗焦虑药物，常用于治疗广泛性焦虑症。许多研究发现，在治疗这种疾病方面，它的疗效与苯二氮䓬类药物相当。由于其副作用相对较轻且可耐受，在过去几年中它越来越受到青睐。作者报告了一例丁螺环酮过量服用的病例，患者在服药后约36小时出现全身性强直阵挛性发作。虽然此前尚无丁螺环酮导致人类癫痫发作的病例，但存在这种现象的动物模型。作者描述了该病例，回顾了有关丁螺环酮过量和毒性的文献，并讨论了治疗建议。
