Zoofaghari Shafeajafar, Wong Anselm, Kiarasi Pegah, Gheshlaghi Farzad
Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Emergency Department, Austin Toxicology Unit, Victorian Poisons Information Centre, Austin Health, Victoria, Australia.
J Res Pharm Pract. 2020 Oct 8;9(3):161-164. doi: 10.4103/jrpp.JRPP_20_24. eCollection 2020 Jul-Sep.
Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to the overuse of citalopram. The patient had bilateral anterior shoulder dislocation along with right proximal humerus fracture that was occurred during the seizure. The dislocation was initially reduced and then fixed. Moreover, the seizure was controlled with diazepam without any problems, and cardiac monitoring continued for 2 days. Massive citalopram overdose may be associated with recurrent seizures and QT prolongation. Complications postseizures, such as shoulder dislocations, should be examined for and managed appropriately.
选择性5-羟色胺再摄取抑制剂（SSRIs）被广泛用于治疗多种类型的精神障碍。西酞普兰在这方面常被用作新一代的SSRIs；然而，不幸的是，其过量服用与癫痫发作和心脏疾病有关。本研究报告的病例表明，由于过量使用西酞普兰，出现了反复癫痫发作、非特异性ST-T改变以及QT间期延长。该患者在癫痫发作期间出现双侧肩关节前脱位以及右肱骨近端骨折。脱位最初得到复位，然后进行了固定。此外，癫痫发作通过地西泮得到控制，没有出现任何问题，心脏监测持续了2天。大量西酞普兰过量服用可能与反复癫痫发作和QT间期延长有关。对于癫痫发作后的并发症，如肩关节脱位，应进行检查并适当处理。
