Kise Yoshifumi, Yoshimura Shinichi, Akieda Kazuki, Umezawa Kazuo, Okada Ken-ichi, Yoshitake Noriyuki, Shiramizu Hideki, Yamamoto Isotoshi, Inokuchi Sadaki
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan.
J Emerg Med. 2004 Feb;26(2):183-7. doi: 10.1016/j.jemermed.2003.07.002.
A 48-year-old woman presented after taking 2000 mg of selenium dioxide, corresponding to 10 times the experimental lethal dose in animals. She presented with mildly altered consciousness and hematemesis. Endoscopy revealed mucosal damage throughout the oral cavity, esophagus, and stomach. There was no evidence of perforation. After intubation and gastric lavage, hemodialysis was performed. The patient was discharged uneventfully on the 16(th) day. This case highlights a very rare acute selenium intoxication. Serum and urinary selenium levels and serum glutathione peroxidase activities during the patient's course were followed, as well as the mucosal corrosive damage caused by the selenium.
一名48岁女性在摄入2000毫克二氧化硒后就诊，这相当于动物实验致死剂量的10倍。她表现为意识轻度改变和呕血。内镜检查显示口腔、食管和胃均有黏膜损伤。没有穿孔的证据。插管和洗胃后，进行了血液透析。患者于第16天顺利出院。该病例凸显了一种极为罕见的急性硒中毒。在患者病程中监测了血清和尿液中的硒水平以及血清谷胱甘肽过氧化物酶活性，还有硒造成的黏膜腐蚀性损伤。
