Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Oxid Med Cell Longev. 2022 Jul 6;2022:7009863. doi: 10.1155/2022/7009863. eCollection 2022.
Selenium (Se), in the form of selenoproteins, is an essential micronutrient that plays an important role in human health and disease. To date, there are at least 25 selenoproteins in humans involved in a wide variety of biological functions, including mammalian development, metabolic progress, inflammation response, chemoprotective properties, and most notably, oxidoreductase functions. In recent years, numerous studies have reported that low Se levels are associated with increased risk, poor outcome, and mortality of metabolic disorders, mainly related to the limited antioxidant defense resulting from Se deficiency. Moreover, the correlation between Se deficiency and Keshan disease has received considerable attention. Therefore, Se supplementation as a therapeutic strategy for preventing the occurrence, delaying the progression, and alleviating the outcomes of some diseases has been widely studied. However, supranutritional levels of serum Se may have adverse effects, including Se poisoning. This review evaluates the correlation between Se status and human health, with particular emphasis on the antioxidant benefits of Se in metabolic disorders, shedding light on clinical treatment.
硒（Se）以硒蛋白的形式存在，是一种必需的微量元素，在人类健康和疾病中起着重要作用。迄今为止，人类体内至少有 25 种硒蛋白，涉及多种生物学功能，包括哺乳动物发育、代谢进展、炎症反应、化学保护特性，以及最显著的氧化还原酶功能。近年来，许多研究报告指出，低硒水平与代谢紊乱风险增加、预后不良和死亡率升高有关，主要与硒缺乏导致的抗氧化防御有限有关。此外，硒缺乏与克山病之间的相关性引起了广泛关注。因此，硒补充作为一种预防某些疾病发生、延缓进展和减轻其后果的治疗策略已得到广泛研究。然而，血清硒的超营养水平可能会产生不良影响，包括硒中毒。本综述评估了硒状态与人类健康之间的相关性，特别强调了硒在代谢紊乱中的抗氧化益处，为临床治疗提供了启示。
