Wang Huei-Shyong, Kuo Meng-Fai
Division of (Pediatric) Neurology, Chang Gung Children's Hospital, Chang Gung University, Taiwan.
Brain Dev. 2003 Dec;25 Suppl 1:S29-31. doi: 10.1016/s0387-7604(03)90005-2.
We have done an epidemiological study in an elementary school with 2000 Taiwanese children aged from 6 to 12 years, and found 11 of them with Tourette's syndrome. The prevalence rate of Tourette's syndrome was around 0.56%. The ratio of male to female was 9 to 2. The comorbid rate of attention-deficit/hyperactivity disorder was 36%, self-injurious behaviors 27%, and obsessive-compulsive behaviors 18%. The familial rate of Tourette's syndrome was 27%. We also found that another 98 children had transient tic disorders. For 73% of patients with mild tics, understanding and acceptance from family, teachers, and friends are the most important things. When tics are so severe that medication is necessary, haloperidol is no longer the first or only choice. We tried clonidine, atypical neuroleptics such as risperidone or olanzapine, or pergolide. The first support group was established in 1999 for children with tics in Taiwan and transformed to Taiwan Tourette Family association in June 2001 to provide further service for Tourette's syndrome.
我们对一所拥有2000名6至12岁台湾儿童的小学进行了一项流行病学研究,发现其中11名患有抽动秽语综合征。抽动秽语综合征的患病率约为0.56%。男女比例为9比2。注意缺陷多动障碍的共病率为36%,自伤行为为27%,强迫行为为18%。抽动秽语综合征的家族发病率为27%。我们还发现另有98名儿童患有短暂性抽动障碍。对于73%的轻度抽动患者而言,来自家人、老师和朋友的理解与接纳是最为重要的。当抽动严重到需要药物治疗时,氟哌啶醇不再是首选或唯一选择。我们尝试了可乐定、非典型抗精神病药物如利培酮或奥氮平,或培高利特。1999年在台湾为抽动儿童成立了首个支持小组,并于2001年6月转变为台湾抽动秽语综合征家庭协会,为抽动秽语综合征提供进一步服务。