Division of Pediatric Neurology, Chang Gung Children's Hospital at Linkou, Chang Gung University College of Medicine, 5 Fu-Shin Street, Kwei-Shan, Taoyuan, 333, Taiwan.
Division of Pediatric Critical Care and Pediatric Neurocritical Care Center, Chang Gung Children's Hospital at Linkou, Taoyuan, Taiwan.
Soc Psychiatry Psychiatr Epidemiol. 2022 Aug;57(8):1711-1721. doi: 10.1007/s00127-022-02253-7. Epub 2022 Apr 25.
The incidence of Tourette syndrome and chronic tic disorders has seldom been evaluated in Asia.
Using the National Taiwan Insurance Research Database, the annual standardized incidence and prevalence of Tourette syndrome (TS) and chronic tic disorders were estimated from 2007 to 2015. The pre-existing comorbidity at disease diagnosis was also evaluated.
From 2007 to 2015, the age- and sex-standardized incidence increased from 5.34 (95% confidence interval [CI] 5.06-5.62) per 100,000 person-years to 6.87 (95% CI 6.53-7.21) per 100,000 person-years. In children and adolescents, the age- and sex-standardized incidence increased from 19.58 (95% CI 18.42-20.75) per 100,000 person-years to 31.79 (95% CI 30.09-33.49) per 100,000 person-years. In adults, the age- and sex-standardized incidence decreased from 2.01 (95% CI 1.79-2.23) per 100,000 person-years to 1.24 (95% CI 1.07-1.42) per 100,000 person-years. The incidence rate ratio (IRR) between males and females was 3.74 (95% CI 3.32-4.22). The age- and sex-standardized prevalence increased from 37.51 (95% CI 36.75-38.27) per 100,000 people in 2007 to 84.18 (95% CI 83.02-85.35) per 100,000 people in 2015. The rate risk (RR) between males and females was 3.65 (95% CI 3.53-3.78).
The annual incidence rates of TS and chronic tic disorders increased in childhood and adolescence but decreased in adulthood from 2007 to 2015. The prevalence rates increased over the same period.
抽动秽语综合征和慢性抽动障碍的发病率在亚洲鲜有评估。
利用全民健康保险研究数据库，自 2007 年至 2015 年，估计了抽动秽语综合征（TS）和慢性抽动障碍的年发病率和患病率（发病率和患病率经年龄和性别标准化）。还评估了疾病诊断时的预先存在的合并症。
2007 年至 2015 年，年龄和性别标准化发病率从 5.34（95%置信区间[CI]5.06-5.62）/100000 人年增加至 6.87（95%CI6.53-7.21）/100000 人年。在儿童和青少年中，年龄和性别标准化发病率从 19.58（95%CI18.42-20.75）/100000 人年增加至 31.79（95%CI30.09-33.49）/100000 人年。在成年人中，年龄和性别标准化发病率从 2.01（95%CI1.79-2.23）/100000 人年降低至 1.24（95%CI1.07-1.42）/100000 人年。男女之间的发病率比值（IRR）为 3.74（95%CI3.32-4.22）。2007 年，年龄和性别标准化患病率为 37.51（95%CI36.75-38.27）/100000 人，至 2015 年增加至 84.18（95%CI83.02-85.35）/100000 人。男女之间的风险比（RR）为 3.65（95%CI3.53-3.78）。
2007 年至 2015 年，TS 和慢性抽动障碍的年发病率在儿童和青少年中增加，但在成年期下降。同期患病率增加。
