Le Bris Hervé, Pouliquen Hervé
UMR INRA/ENVN Chimiothérapie Aquacole et Environnement, Ecole Nationale Vétérinaire de Nantes, BP 40706 Atlanpole, La Chantrerie, 44307 Nantes Cedex 03, France.
Mar Pollut Bull. 2004 Mar;48(5-6):434-40. doi: 10.1016/j.marpolbul.2003.08.018.
The ability of blue mussel (Mytilus edulis) to act as a potential antibiotic bioindicator in marine waters was experimentally tested by the study of the kinetics of two veterinary antibiotics (oxolinic acid: OA and oxytetracycline: OTC). Antibiotic uptake was fast in the soft parts of the mussels. OA was quickly eliminated while OTC was released more slowly (half-life in viscera=3.9 days). OA and OTC were preferentially accumulated in gills and in viscera, respectively. Bio-accumulation factors were low (maximum: 2 for OTC in viscera) in accordance with the low K(ow)s. It was assumed that the higher OTC bioaccumulation pattern was related to its binding to mineral and organic compounds that led to its activity inhibition (62%). The antibiotics were persistent in shells (OTC half-life=8.3 days). Most veterinary and human antibiotics such as tetracyclines and sulphonamides have low log K(ow)(<2) and should weakly accumulate in mussel. This might limit the use of blue mussel to bio-monitor antibiotics in the marine environment.
通过研究两种兽用抗生素（恶喹酸：OA和土霉素：OTC）的动力学，对蓝贻贝（紫贻贝）作为海水中潜在抗生素生物指示物的能力进行了实验测试。抗生素在贻贝的软组织中吸收迅速。OA很快被消除，而OTC释放得更慢（在内脏中的半衰期=3.9天）。OA和OTC分别优先积累在鳃和内脏中。根据低辛醇-水分配系数，生物累积因子较低（最大值：内脏中OTC为2）。据推测，较高的OTC生物累积模式与其与矿物质和有机化合物的结合有关，这导致其活性受到抑制（62%）。抗生素在贝壳中具有持久性（OTC半衰期=8.3天）。大多数兽用和人用抗生素，如四环素和磺胺类药物，辛醇-水分配系数对数较低（<2），在贻贝中的累积应该较弱。这可能会限制蓝贻贝在海洋环境中用于生物监测抗生素的用途。
