1-O-乙酰基大不列颠内酯及其衍生物（2-O-丁基肟-3-苯基）-丙酰基-1-O-乙酰基大不列颠内酯酯的研究。
Studies on 1-O-acetylbritannilactone and its derivative, (2-O-butyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone ester.
作者信息
Liu Shouxin, Liu He, Yan Weiying, Zhang Li, Bai Naisheng, Ho Chi-Tang
机构信息
Hebei University of Science and Technology, Shijiazhuan 050018, People's Republic of China.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1101-4. doi: 10.1016/j.bmcl.2003.12.078.
The crystal structures of 1-O-acetylbritannilactone 6 isolated from Inula britannica, and its derivative (2-O-butyloxime-3-phenyl) propionyl 1-O-acetylbritannilactone ester 7 are reported. The structure of synthesized derivative 7 was established by spectroscopic methods. Both compounds inhibited the growth of human HL-60, Bel-7402 cell lines and compound 7 had the stronger cytotoxic activity.
报道了从旋覆花中分离得到的1-O-乙酰基大花旋覆花内酯6及其衍生物（2-O-丁基肟-3-苯基）丙酰基1-O-乙酰基大花旋覆花内酯酯7的晶体结构。通过光谱方法确定了合成衍生物7的结构。两种化合物均抑制人HL-60、Bel-7402细胞系的生长，且化合物7具有更强的细胞毒活性。
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