贯叶连翘中的 Phillylactones C 和 D 及其他细胞毒素化合物。

Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica.

机构信息

Instituto de Química, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., Mexico.

出版信息

Steroids. 2011 Jun;76(7):724-8. doi: 10.1016/j.steroids.2011.03.018. Epub 2011 Apr 7.

DOI:10.1016/j.steroids.2011.03.018

Abstract

Two new withanolides, philadelphicalactone C (1) and philadelphicalactone D (4), along with the known withaphysacarpin (3), ixocarpanolide (5), philadelphicalactone A (6), and ixocarpalactone A (7) were isolated from the aerial parts of Physalis philadelphica Lam. Structures of these compounds were determined by spectroscopic analyses and that of philadelphicalactone C (1) was confirmed by X-ray crystallographic analysis. Evaluation of the cytotoxic activity of all isolates and the derivative 2 against a panel of human cancer cell lines indicated a potent activity of compounds 2, 3, 6, and 7.

摘要

从灯笼草（Physalis philadelphica Lam.）的地上部分分离得到两个新的羽扇豆烷内酯，即 philadelphicalactone C（1）和 philadelphicalactone D（4），以及已知的 withaphysacarpin（3）、ixocarpanolide（5）、philadelphicalactone A（6）和 ixocarpalactone A（7）。通过光谱分析确定了这些化合物的结构，其中 philadelphicalactone C（1）的结构通过 X 射线晶体学分析得到了确证。对所有分离物和衍生物 2 对一系列人类癌细胞系的细胞毒性活性评估表明，化合物 2、3、6 和 7 具有很强的活性。