Ayalon Liat, Doron Ravid, Weiner Ina, Joel Daphna
Department of Psychology, Tel-Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel.
Exp Neurol. 2004 Mar;186(1):46-58. doi: 10.1016/S0014-4886(03)00312-1.
Four groups of rats, sustaining a striatal quinolinic acid (QA) lesion, a pallidal QA lesion, a combined striatal + pallidal lesion, or sham operation, were tested in spontaneous and amphetamine-induced activity, spatial navigation in a water maze, position discrimination and reversal in a wet T maze, and food manipulation. The striatal lesion markedly impaired rats' performance on the motor and cognitive tasks. In contrast, rats sustaining a bilateral lesion to the GP in addition to the striatal lesion performed similarly to sham-operated rats on the motor and cognitive tasks, although they showed a transient decrease in activity levels. Given that a similar dysfunction of basal ganglia circuitry is thought to subserve the behavioral alterations seen in QA-lesioned rats and Huntington's disease (HD) patients, the present results raise the possibility that manipulations of the external segment of the globus pallidus (the primate analogue of the rat GP) could ameliorate some of HD symptoms.
四组大鼠分别接受纹状体喹啉酸（QA）损伤、苍白球QA损伤、纹状体+苍白球联合损伤或假手术，然后对它们进行自发活动和安非他明诱导的活动测试、水迷宫中的空间导航测试、湿T迷宫中的位置辨别和逆转测试以及食物操作测试。纹状体损伤显著损害了大鼠在运动和认知任务上的表现。相比之下，除纹状体损伤外还接受双侧苍白球损伤的大鼠在运动和认知任务上的表现与假手术大鼠相似，尽管它们的活动水平出现了短暂下降。鉴于基底神经节回路的类似功能障碍被认为是QA损伤大鼠和亨廷顿舞蹈病（HD）患者行为改变的原因，目前的结果增加了这样一种可能性，即对苍白球外部段（大鼠苍白球的灵长类动物对应物）进行操作可能会改善HD的一些症状。
