Kammermeyer J K, Rajtora D W, Anuras J, Richerson H B
J Allergy Clin Immunol. 1977 Apr;59(4):287-93. doi: 10.1016/0091-6749(77)90049-5.
A double-blind, vehicle control, parallel clinical trial evaluated the effectiveness and safety of the local application of flunisolide, a potent new topical steroid, in the treatment of ragweed hay fever. Fifty patients with well-defined, poorly controlled ragweed allergy were studied during the 1974 ragweed season. Analysis of the data showed that the active drug group had a significant decrease in individual symptoms of sneezing, nasal stuffiness, and nasal secretions, compared with the placebo group. Antihistamine usage was statistically decreased in the active drug over placebo group. There was no evidence of adrenal suppression. This study indicates that intranasal administration of flunisolide in adult patients is both efficacious and safe in the treatment of seasonal allergic rhinitis.
一项双盲、以赋形剂为对照的平行临床试验评估了强效新型局部用类固醇氟尼缩松局部应用于治疗豚草花粉热的有效性和安全性。在1974年豚草花粉季节对50例明确诊断为豚草过敏且病情控制不佳的患者进行了研究。数据分析表明，与安慰剂组相比，活性药物组在打喷嚏、鼻塞和鼻分泌物等个体症状方面有显著减轻。活性药物组与安慰剂组相比，抗组胺药的使用在统计学上有所减少。没有肾上腺抑制的证据。这项研究表明，成年患者鼻内给予氟尼缩松治疗季节性变应性鼻炎既有效又安全。
