Welsh P W, Stricker W E, Chu C P, Naessens J M, Reese M E, Reed C E, Marcoux J P
Mayo Clin Proc. 1987 Feb;62(2):125-34. doi: 10.1016/s0025-6196(12)61882-5.
Although three effective topical treatments for allergic rhinitis are available, little information to assist the clinician in choosing among them has been reported. Therefore, we conducted a randomized clinical trial to compare beclomethasone nasal solution, flunisolide, and cromolyn with placebo in 120 patients with hay fever during the ragweed season of 1984. We found that all three agents were superior to placebo (P less than 0.001) and that the glucocorticoids were more effective than cromolyn (P less than 0.001). Surprisingly, we also found that these intranasal treatments considerably reduced the symptoms of seasonal asthma. Further study of this therapeutic advantage is needed.
虽然有三种有效的过敏性鼻炎局部治疗方法，但关于帮助临床医生在它们之间进行选择的信息报道甚少。因此，我们进行了一项随机临床试验，于1984年豚草季节在120例花粉症患者中比较了倍氯米松鼻溶液、氟尼缩松和色甘酸钠与安慰剂的疗效。我们发现所有三种药物均优于安慰剂（P<0.001），且糖皮质激素比色甘酸钠更有效（P<0.001）。令人惊讶的是，我们还发现这些鼻内治疗能显著减轻季节性哮喘的症状。需要对这一治疗优势进行进一步研究。
