Jacobus N V, McDermott L A, Ruthazer R, Snydman D R
Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.
Antimicrob Agents Chemother. 2004 Mar;48(3):1034-6. doi: 10.1128/AAC.48.3.1034-1036.2004.
The in vitro activities of tigecycline were tested against 831 isolates of the Bacteroides fragilis group representing all of the species within the group. On a weight-to-weight basis (8 microg/ml), tigecycline was more active than clindamycin, minocycline, trovafloxacin, and cefoxitin and less active than imipenem or piperacillin-tazobactam against all isolates of the B. fragilis group. Tigecycline geometric mean MICs were statistically higher against B. distasonis than other Bacteroides species (P value of 0.0001).
针对代表脆弱拟杆菌群内所有物种的831株脆弱拟杆菌群菌株，测试了替加环素的体外活性。以重量对重量计（8微克/毫升），替加环素对所有脆弱拟杆菌群菌株的活性高于克林霉素、米诺环素、曲伐沙星和头孢西丁，而低于亚胺培南或哌拉西林-他唑巴坦。替加环素的几何平均最低抑菌浓度（MIC）对狄氏拟杆菌的统计学结果高于其他拟杆菌属物种（P值为0.0001）。
