Bourgault A M, Lamothe F, Hoban D J, Dalton M T, Kibsey P C, Harding G, Smith J A, Low D E, Gilbert H
Hôpital Saint-Luc, Montréal, Québec, Canada.
Antimicrob Agents Chemother. 1992 Feb;36(2):343-7. doi: 10.1128/AAC.36.2.343.
The in vitro activities of penicillin, clindamycin, chloramphenicol, metronidazole, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin-sulbactam, cefoxitin, ceftizoxime, cefotetan, moxalactam, and imipenem against 348 Bacteroides fragilis group isolates collected from six Canadian cities during 1990 were determined by the National Committee for Clinical Laboratory Standards (NCCLS) agar dilution technique. All isolates were susceptible to chloramphenicol, metronidazole, piperacillin-tazobactam, and imipenem. For the other antibiotics tested, the following resistance rates were observed: penicillin, 97%; clindamycin, 9%; piperacillin, 19%; ticarcillin, 31%; ticarcillin-clavulanate, 0.28%; ampicillin-sulbactam, 0.85%; cefoxitin, 26%; ceftizoxime, 15%; cefotetan, 53%; and moxalactam, 17%. Susceptibility profiles to beta-lactam antibiotics varied among the different species tested: B. fragilis and Bacteroides vulgatus demonstrated lower resistance rates than Bacteroides distasonis and indole-positive Bacteroides thetaiotaomicron and Bacteroides ovatus. Ceftizoxime results should be interpreted cautiously, because the MICs obtained with the recommended NCCLS control strain were lower than expected.
采用美国国家临床实验室标准委员会（NCCLS）琼脂稀释法，测定了1990年从加拿大6个城市收集的348株脆弱拟杆菌属菌株对青霉素、克林霉素、氯霉素、甲硝唑、哌拉西林、哌拉西林-他唑巴坦、替卡西林、替卡西林-克拉维酸、氨苄西林-舒巴坦、头孢西丁、头孢唑肟、头孢替坦、莫西沙星和亚胺培南的体外活性。所有菌株对氯霉素、甲硝唑、哌拉西林-他唑巴坦和亚胺培南敏感。对于其他测试抗生素，观察到以下耐药率：青霉素，97%；克林霉素，9%；哌拉西林，19%；替卡西林，31%；替卡西林-克拉维酸，0.28%；氨苄西林-舒巴坦，0.85%；头孢西丁，26%；头孢唑肟，15%；头孢替坦，53%；莫西沙星，17%。不同测试菌种对β-内酰胺类抗生素敏感性不同：脆弱拟杆菌和普通拟杆菌的耐药率低于狄氏拟杆菌、产吲哚栖瘤胃拟杆菌和卵形拟杆菌。头孢唑肟结果应谨慎解读，因为使用推荐的NCCLS对照菌株获得的最低抑菌浓度低于预期。
