粘叶九里香素，一种来自粘叶红厚壳（山竹子科）的新香豆素。

Mucigerin, a new coumarin from Calophyllum mucigerum (Guttiferae).

作者信息

Ee G C L, Ng K N, Taufiq-Yap Y H, Rahmani M, Ali A M, Muse R

机构信息

Department of Chemistry, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

出版信息

Nat Prod Res. 2004 Apr;18(2):123-8. doi: 10.1080/1478641031000149876.

DOI:10.1080/1478641031000149876

PMID:14984084

Abstract

Our recent studies on the stem bark of Calophyllum mucigerum (Guttiferae) have yielded a new coumarin mucigerin, a prenylated xanthone cudraxanthone C and the common steroidal triterpenes friedelin and stigmasterol. Structural elucidations of these compounds were achieved using 1H NMR, 13C NMR, DEPT, COSY, HETCOR and HMBC experiments while MS gave the molecular masses. Cytotoxic assays using CEM-SS cell line (T-lymphoblastic leukemia) on the crude extracts of the stem bark indicated some activity. The crude extracts were also found to be moderately toxic against the larvae of Aedes aegypti. This article reports the isolation and identification of mucigerin as well as bioassay data.

摘要

我们最近对粘叶红厚壳（金丝桃科）茎皮的研究得到了一种新的香豆素粘叶素、一种异戊烯基呫吨酮库拉索呫吨酮C以及常见的甾体三萜类化合物木栓酮和豆甾醇。通过1H NMR、13C NMR、DEPT、COSY、HETCOR和HMBC实验对这些化合物进行了结构解析，而质谱给出了分子量。使用CEM-SS细胞系（T淋巴细胞白血病）对茎皮粗提物进行的细胞毒性试验表明有一定活性。还发现粗提物对埃及伊蚊幼虫有中等毒性。本文报道了粘叶素的分离鉴定以及生物测定数据。