一种从红厚壳茎皮中提取的新呋喃呫吨酮。

A new furanoxanthone from the stem bark of Calophyllum inophyllum.

作者信息

Ee Gwendoline Cheng Lian, Mah Siau Hui, Rahmani Mawardi, Taufiq-Yap Yun Hin, Teh Soek Sin, Lim Yang Mooi

机构信息

Department of Chemistry, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

出版信息

J Asian Nat Prod Res. 2011 Oct;13(10):956-60. doi: 10.1080/10286020.2011.600248.

DOI:10.1080/10286020.2011.600248

PMID:21972812

Abstract

The stem bark extracts of Calophyllum inophyllum furnished one new furanoxanthone, inophinnin (1), in addition to inophyllin A (2), macluraxanthone (3), pyranojacareubin (4), 4-hydroxyxanthone, friedelin, stigmasterol, and betulinic acid. The structures of these compounds were determined by spectroscopic analysis of 1D and 2D NMR spectral data ((1)H, (13)C, DEPT, COSY, HMQC, and HMBC) while EI-MS gave the molecular mass. The new xanthone, inophinnin (1), exhibited some anti-inflammatory activity in nitric oxide assay.

摘要

红厚壳的茎皮提取物除了含有红厚壳素A（2）、桑色素（3）、吡喃雅卡里红素（4）、4-羟基呫吨酮、木栓酮、豆甾醇和桦木酸外，还提供了一种新的呋喃呫吨酮，即红厚壳素（1）。这些化合物的结构通过一维和二维核磁共振光谱数据（（1）H、（13）C、DEPT、COSY、HMQC和HMBC）的光谱分析确定，而电子轰击质谱给出了分子量。新的呫吨酮红厚壳素（1）在一氧化氮测定中表现出一定的抗炎活性。