Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Rio Grande do Sul, Brazil.
Parasitol Res. 2013 Jun;112(6):2367-71. doi: 10.1007/s00436-013-3401-8. Epub 2013 Apr 5.
In this study, the larvicidal activity of an enriched fraction of the major lipophilic phenolic compounds from Hypericum carinatum Griseb. (Clusiaceae) was investigated against larvae of Aedes aegypti (Diptera: Culicidae), the main vector of dengue virus in Brazil. The larval mortality rate ranged 37.33 to 72.00 % at concentrations of 66-200 μg/mL. The effect demonstrated to be dose-dependent. The lethal concentration 50 % and confidence interval were 100 and 88-111 μg/mL, respectively. The results could be attributed to the presence of cariphenone A and cariphenone B in concentrations of 1.24 ± 0.04 and 0.56 ± 0.01 %, respectively, determined by high-performance liquid chromatography. Besides, the results reinforce the potential of genus Hypericum as source of alternative insecticides.
本研究调查了从 Hypericum carinatum Griseb.（藤黄科）中提取的富含主要亲脂性酚类化合物的富集体对巴西登革热病毒主要传播媒介埃及伊蚊幼虫的杀幼虫活性。在 66-200μg/mL 的浓度下，幼虫死亡率范围为 37.33%至 72.00%。该效果呈剂量依赖性。半数致死浓度和置信区间分别为 100μg/mL 和 88-111μg/mL。结果可归因于存在浓度分别为 1.24±0.04μg/mL 和 0.56±0.01μg/mL 的 cariphenone A 和 cariphenone B，这是通过高效液相色谱法确定的。此外，这些结果增强了 Hypericum 属作为替代杀虫剂来源的潜力。
