Manfredi Roberto, Calza Leonardo, Chiodo Francesco
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna "Alma Mater Studiorum", S. Orsola Hospital, Bologna, Italy.
Infez Med. 2003 Sep;11(3):153-6.
Two exceedingly rare cases of dual AIDS-associated neoplasms (Kaposi's sarcoma and non-Hodgkin's lymphoma), occurring in a short time as AIDS-defining diseases of two HIV-infected patients treated with highly active antiretroviral therapy (HAART) are reported and discussed in light of evidence from the available literature. A slowly progressive increase in neoplastic complications following the introduction of HAART and the consequent decline of opportunistic infections such as the main AIDS-related disorders has been observed, and combined cancer diseases may be expected in the next few years, due to the persistent dysregulation of the immune system, or a possible involvement of oncoviruses and HIV itself in the pathogenesis of HIV-associated cancer.
报告了两例极其罕见的双重艾滋病相关肿瘤（卡波西肉瘤和非霍奇金淋巴瘤）病例，这两种肿瘤在短时间内作为两名接受高效抗逆转录病毒治疗（HAART）的HIV感染患者的艾滋病定义疾病出现，并根据现有文献证据进行了讨论。随着HAART的引入以及随之而来的机会性感染（如主要的艾滋病相关疾病）的减少，肿瘤并发症呈缓慢进展性增加，由于免疫系统持续失调，或致癌病毒和HIV本身可能参与HIV相关癌症的发病机制，预计未来几年可能会出现合并癌症疾病。
