Department of Infectious Diseases, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, Korea.
Department of Pathology, Chonnam National University Medical School, Gwangju, Republic of Korea.
BMC Cancer. 2018 Nov 8;18(1):1080. doi: 10.1186/s12885-018-5019-9.
The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression.
We report a case of dual primary ADCs, especially NHL followed by KS, in a 70-year-old HIV-infected man who was on antiretroviral therapy and had successful virologic suppression. During HAART, he presented with generalized myalgia and abdominal pain. Multiple liver masses were detected and a biopsy revealed Burkitt's lymphoma. After three cycles of anticancer chemotherapy with a favorable response, he was diagnosed with cytomegalovirus retinitis and the anti-cancer chemotherapy was discontinued. Despite successful virologic suppression with HAART, human herpes virus-8 associated Kaposi's sarcoma was diagnosed in his right thigh. He underwent radiation therapy.
These findings suggest that multiple ADCs can occur in PWHA who are receiving HAART and have successful virologic suppression. Healthcare providers caring for PWHA should maintain vigilance for the development of a broad spectrum of cancers.
在高效抗逆转录病毒治疗（HAART）时代，艾滋病定义性癌症（ADCs）的发病率显著下降。在严重免疫抑制或病毒学抑制不完全的 HIV 感染者或艾滋病患者（PWHAs）中，两种 ADC 的发生非常罕见。
我们报告了一例 70 岁 HIV 感染男性的双重原发性 ADC，特别是 NHL 继 KS 之后，该患者正在接受抗病毒治疗且病毒学抑制成功。在 HAART 期间，他出现全身肌肉疼痛和腹痛。检测到多个肝肿块，活检显示伯基特淋巴瘤。经过三个周期的抗癌化疗后，反应良好，他被诊断出患有巨细胞病毒视网膜炎，停止了抗癌化疗。尽管 HAART 实现了成功的病毒学抑制，但他的右大腿被诊断出与人疱疹病毒 8 相关的卡波西肉瘤。他接受了放射治疗。
这些发现表明，在接受 HAART 且病毒学抑制成功的 PWHAs 中，可能会发生多种 ADC。照顾 PWHAs 的医疗保健提供者应保持警惕，注意广谱癌症的发生。
