Handelsman L, Horvath T, Aronson M, Schroeder M, Jacobson J, Wiener J, Peterson A, Holloway K, Ness R, Herman S
Psychiatry, Service, Veterans Affairs Medical Center, Bronx, NY 10468.
J Neuropsychiatry Clin Neurosci. 1992 Summer;4(3):294-302. doi: 10.1176/jnp.4.3.294.
Features of event-related potentials (ERPs) may be sensitive and clinically useful markers of central nervous system infection by the human immunodeficiency virus (HIV-1); however, this application has not been studied in the risk group of intravenous drug users. Auditory ERPs generated by an "oddball" paradigm were analyzed for 39 male drug abusers as part of a multimodal assessment. Stage of HIV-1 infection was associated with prolongations of P1, N1, and P3 components of the ERP waveform. Only patients with full acquired immunodeficiency syndrome showed statistically significant increases in waveform prolongations. Specific neuropsychological deficits were not related to waveform latency prolongations.
事件相关电位（ERP）的特征可能是人类免疫缺陷病毒（HIV-1）引起的中枢神经系统感染的敏感且具有临床实用性的标志物；然而，尚未在静脉吸毒者这一风险群体中对该应用进行研究。作为多模式评估的一部分，对39名男性吸毒者由“oddball”范式产生的听觉ERP进行了分析。HIV-1感染阶段与ERP波形的P1、N1和P3成分延长有关。只有完全获得性免疫缺陷综合征患者的波形延长有统计学上的显著增加。特定的神经心理学缺陷与波形潜伏期延长无关。
