Schroeder M M, Handelsman L, Torres L, Dorfman D, Rinaldi P, Jacobson J, Wiener J, Ritter W
Psychiatry Services, Veteran Affairs Medical Center, Bronx, NY 10468.
Biol Psychiatry. 1994 Jan 1;35(1):54-69. doi: 10.1016/0006-3223(94)91168-1.
HIV-1 (Human immunodeficiency virus) infection of the brain causes delays in auditory event-related potential (ERP) components. We recorded auditory ERPs from 38 former parenteral drug users (PDUs) at three stages of HIV-1 infection: seronegative; seropositive; stage II; and seropositive, stage IV. There were five response conditions: Go Nogo, Count, Simple Response, Simple Count, and Ignore. P3 peak latencies were significantly delayed and P3 amplitudes were significantly reduced for all seropositives, including asymptomatics, when compared to PDU seronegative controls. In contrast, the P1 and N1 peak latency measures were delayed only for seropositives with acquired immunodeficiency syndrome (AIDS) qualifying illnesses. There was a significant negative correlation between the CD4 count and the latency of P1, N1, and the MMN. Also, increased P1 and N1 amplitudes correlated with indices of disease progression (Choice RT and CD4 counts, respectively). The results extend previous findings by clarifying the pattern of auditory ERP markers of disease progression. Early, as well as late, brain involvement caused by HIV-1 is marked by delays and decreased amplitudes in cognitive components. In addition, late brain involvement is marked by delays and increased amplitudes in specific, automatic, and/or obligatory components.
人类免疫缺陷病毒1型（HIV-1）感染大脑会导致听觉事件相关电位（ERP）成分出现延迟。我们记录了38名曾使用过注射毒品的人（PDU）在HIV-1感染三个阶段的听觉ERP：血清阴性；血清阳性，II期；血清阳性，IV期。有五种反应条件：“执行-不执行”任务、计数任务、简单反应任务、简单计数任务和忽略任务。与血清阴性的PDU对照组相比，所有血清阳性者（包括无症状者）的P3波峰潜伏期显著延迟，P3波幅显著降低。相比之下，只有患有获得性免疫缺陷综合征（AIDS）相关疾病的血清阳性者的P1和N1波峰潜伏期测量值出现延迟。CD4细胞计数与P1、N1和失匹配负波（MMN）的潜伏期之间存在显著负相关。此外，P1和N1波幅增加分别与疾病进展指标（选择反应时和CD4细胞计数）相关。这些结果通过阐明疾病进展的听觉ERP标志物模式扩展了先前的研究发现。HIV-1引起的早期和晚期脑损伤均表现为认知成分的延迟和波幅降低。此外，晚期脑损伤的特征是特定的、自动的和/或强制性成分出现延迟和波幅增加。
