Ragazzoni A, Grippo A, Ghidini P, Schiavone V, Lolli F, Mazzotta F, Mecocci L, Pinto F
Department of Neurological and Psychiatric Science, University of Florence, Italy.
Acta Neurol Scand. 1993 Jan;87(1):47-51. doi: 10.1111/j.1600-0404.1993.tb04074.x.
EEGs, brainstem auditory evoked potentials (BAEPs) and auditory event-related potentials (ERPs) were recorded from 33 individuals infected with the human immunodeficiency virus, type 1 (HIV1+ patients: 13 CDC Class II or III; 20 Class IV). All were neurologically asymptomatic, non-demented, and had a past history of intravenous drug abuse. Sixteen age- and sex-matched normals and 10 HIV1- former drug addicts served as controls. Half of the HIV1+ and HIV1- subjects displayed mild EEG anomalies and, except for one HIV1+ patient, BAEPs were normal in both groups. ERPs were normal in all HIV1- subjects but anomalous (longer latencies of components P2, N2, P3; reduced amplitude of P3) in 9 HIV1+ patients (27%), the incidence of such anomalies being higher for Class IV than Class II/III patients. Auditory ERPs proved the most sensitive and specific of these electrophysiological procedures in detecting subclinical central nervous system involvement in HIV1 infection.
对33名感染1型人类免疫缺陷病毒的个体进行了脑电图（EEG）、脑干听觉诱发电位（BAEP）和听觉事件相关电位（ERP）记录（HIV1+患者：13例疾病控制与预防中心（CDC）II级或III级；20例IV级）。所有患者均无神经系统症状、无痴呆，且有静脉药物滥用史。16名年龄和性别匹配的正常人和10名HIV1-既往吸毒者作为对照。一半的HIV1+和HIV1-受试者表现出轻度脑电图异常，除一名HIV1+患者外，两组的BAEP均正常。所有HIV1-受试者的ERP均正常，但9名HIV1+患者（27%）的ERP异常（P2、N2、P3成分潜伏期延长；P3波幅降低），IV级患者此类异常的发生率高于II/III级患者。在检测HIV1感染的亚临床中枢神经系统受累方面，听觉ERP被证明是这些电生理检查中最敏感和特异的。
