Durón Sergio G, Polat Tülay, Wong Chi-Huey
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Org Lett. 2004 Mar 4;6(5):839-41. doi: 10.1021/ol0400084.
N-(phenylthio)-epsilon-caprolactam (1) has been applied as a new promoter for the activation of thioglycosides. This proceeds by the reaction of 1 with trifluoromethansulfonic anhydride, which subsequently activates the thioglycoside for glycosidic bond formation. Notably, the reaction proceeds efficiently at room temperature and is adaptable to our reactivity-based one-pot oligosaccharide synthesis. [reaction: see text]
N-（苯硫基）-ε-己内酰胺（1）已被用作一种新型的硫代糖苷活化促进剂。其作用过程是1与三氟甲磺酸酐反应，随后使硫代糖苷活化以形成糖苷键。值得注意的是，该反应在室温下能高效进行，并且适用于我们基于反应活性的一锅法寡糖合成。[反应：见正文]
