State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd No. 38, Beijing, 100191, China.
Org Biomol Chem. 2011 Jan 21;9(2):616-22. doi: 10.1039/c0ob00380h. Epub 2010 Nov 10.
O,O-Dimethylthiophosphonosulfenyl bromide (DMTPSB) in combination with silver triflate provides a powerful thiophilic promoter system. Both "armed" and "disarmed" thioglycoside glycosyl donors can be activated to form glycosidic linkages efficiently by the pre-activation protocol. The usefulness of this new promoter is illustrated by a successful iterative one-pot oligosaccharide assembly.
O,O-二甲基硫代磷酰基溴（DMTPSB）与三氟甲磺酸银结合形成一种强有力的亲硫促进剂体系。通过预活化方案，“武装”和“解除武装”的硫代糖苷糖基供体都可以被有效激活形成糖苷键。通过成功的迭代一锅法寡糖组装，展示了这种新促进剂的有用性。
