O,O-二甲基硫代磷酰基溴化银三氟甲磺酸酯：一种用于硫代糖苷预活化的新型强效促进剂体系。
O,O-dimethylthiophosphonosulfenyl bromide-silver triflate: a new powerful promoter system for the preactivation of thioglycosides.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd No. 38, Beijing, 100191, China.
出版信息
Org Biomol Chem. 2011 Jan 21;9(2):616-22. doi: 10.1039/c0ob00380h. Epub 2010 Nov 10.
PMID:21069233
Abstract
O,O-Dimethylthiophosphonosulfenyl bromide (DMTPSB) in combination with silver triflate provides a powerful thiophilic promoter system. Both "armed" and "disarmed" thioglycoside glycosyl donors can be activated to form glycosidic linkages efficiently by the pre-activation protocol. The usefulness of this new promoter is illustrated by a successful iterative one-pot oligosaccharide assembly.
摘要
O,O-二甲基硫代磷酰基溴（DMTPSB）与三氟甲磺酸银结合形成一种强有力的亲硫促进剂体系。通过预活化方案，“武装”和“解除武装”的硫代糖苷糖基供体都可以被有效激活形成糖苷键。通过成功的迭代一锅法寡糖组装，展示了这种新促进剂的有用性。
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