一种用于加兰他敏环系的光化学方法。
A photochemical approach to the Galanthan ring system.
作者信息
Minter David E, Winslow Christopher D
机构信息
Department of Chemistry, Texas Christian University, Fort Worth, Texas 76129, USA.
出版信息
J Org Chem. 2004 Mar 5;69(5):1603-6. doi: 10.1021/jo0356560.
PMID:14987017
Abstract
A five-step, atom-efficient synthesis of the Galanthan tetracyclic skeleton has been developed. The key step is an unusual intramolecular de Mayo reaction using an isocarbostyril substrate with a functionalized tether on nitrogen. The target molecule is produced in 35% overall yield from isocarbostyril.
摘要
已开发出一种五步、原子经济的加兰他敏四环骨架合成方法。关键步骤是使用在氮上带有官能化连接链的异咔唑啉底物进行的不寻常的分子内德梅奥反应。目标分子由异咔唑啉以35%的总收率制得。
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