皮肤修复与瘢痕形成：转化生长因子-β的核心作用

Skin repair and scar formation: the central role of TGF-beta.

作者信息

Beanes Steven R, Dang Catherine, Soo Chia, Ting Kang

机构信息

Department of Surgery, UCLA School of Medicine, LA 90095, USA.

出版信息

Expert Rev Mol Med. 2003 Mar 21;5(8):1-22. doi: 10.1017/S1462399403005817.

DOI:10.1017/S1462399403005817

PMID:14987411

Abstract

Wound healing is a complex process that we have only recently begun to understand. Central to wound repair is transforming growth factor beta (TGF-beta), a cytokine secreted by several different cell types involved in healing. TGF-beta has diverse effects, depending upon the tissue studied. This review focuses on healing in skin, particularly the phases of cutaneous wound repair and the role of TGF-beta in normal and impaired wound-healing models. It also explores TGF-beta activity in scarless foetal wound healing. Knowledge of TGF-beta function in scarless repair is critical to improving healing in clinical scenarios, such as diabetic wounds and hypertrophic scars.

摘要

伤口愈合是一个复杂的过程，直到最近我们才开始了解它。伤口修复的核心是转化生长因子β（TGF-β），它是由几种参与愈合的不同细胞类型分泌的一种细胞因子。根据所研究的组织不同，TGF-β具有多种作用。本综述聚焦于皮肤愈合，特别是皮肤伤口修复的阶段以及TGF-β在正常和受损伤口愈合模型中的作用。它还探讨了TGF-β在胎儿无瘢痕伤口愈合中的活性。了解TGF-β在无瘢痕修复中的功能对于改善糖尿病伤口和增生性瘢痕等临床情况下的愈合至关重要。