转化生长因子β（TGF-β）亚型在伤口愈合和纤维化中的作用
Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis.
作者信息
Lichtman Michael K, Otero-Vinas Marta, Falanga Vincent
机构信息
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
Veterans' Administration, Boston Healthcare System, Division of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
出版信息
Wound Repair Regen. 2016 Mar;24(2):215-22. doi: 10.1111/wrr.12398. Epub 2016 Mar 2.
Scar formation, with persistent alteration of the normal tissue structure, is an undesirable and significant result of both wound healing and fibrosing disorders. There are few strategies to prevent or to treat scarring. The transforming growth factor beta (TGF-β) superfamily is an important mediator of tissue repair. Each TGF-β isoform may exert a different effect on wound healing, which may be context-dependent. In particular, TGF-β1 may mediate fibrosis in adults' wounds, while TGF-β3 may promote scarless healing in the fetus and reduced scarring in adults. Thus, TGF-β3 may offer a scar-reducing therapy for acute and chronic wounds and fibrosing disorders.
瘢痕形成会导致正常组织结构的持续改变，是伤口愈合和纤维化疾病不良且显著的结果。预防或治疗瘢痕形成的策略很少。转化生长因子β（TGF-β）超家族是组织修复的重要介质。每种TGF-β异构体对伤口愈合可能产生不同的影响，这可能取决于具体情况。特别是，TGF-β1可能介导成人伤口的纤维化，而TGF-β3可能促进胎儿无瘢痕愈合并减少成人瘢痕形成。因此，TGF-β3可能为急性和慢性伤口以及纤维化疾病提供一种减少瘢痕的治疗方法。
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