[阿根廷一家医院的播散性组织胞浆菌病与艾滋病：临床表现、诊断与治疗]
[Disseminated histoplasmosis and AIDS in an Argentine hospital: clinical manifestations, diagnosis and treatment].
作者信息
Pietrobon Diego, Negro-Marquínez Liliana, Kilstein Jorge, Galíndez Jorge, Greca Alcides, Battagliotti Carlos
机构信息
II Cátedra de Clínica Médica y Terapéutica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
出版信息
Enferm Infecc Microbiol Clin. 2004 Mar;22(3):156-9. doi: 10.1016/s0213-005x(04)73056-6.
We describe 16 HIV-infected patients with disseminated histoplasmosis (14 men, mean age 28 +/- 7.84 years), diagnosed at Hospital Eva Perón in Argentina during the period of October 1993 to July 2000. Disseminated histoplasmosis occurred in 5.3% of HIV-infected patients over the study period. The main symptoms included fever, weight loss and hepatosplenomegaly in 93.8%. Other relevant findings were respiratory compromise (56.3%), digestive symptoms (43.8%), mucocutaneous lesions (75%) and multiple lymphadenopathy (69%). Treatment consisted of amphotericin B 1 mg/kg/day up to a total dose of 1 g, followed by 400 mg/day of oral itraconazole. Mortality in the acute phase was 19% and 37.5% of patients relapsed.
我们描述了1993年10月至2000年7月期间在阿根廷伊娃·庇隆医院诊断出的16例播散性组织胞浆菌病的HIV感染患者（14名男性，平均年龄28±7.84岁）。在研究期间，播散性组织胞浆菌病在5.3%的HIV感染患者中发生。主要症状包括发热、体重减轻和肝脾肿大，占93.8%。其他相关表现为呼吸功能不全（56.3%）、消化系统症状（43.8%）、黏膜皮肤病变（75%）和多处淋巴结病（69%）。治疗包括每天1mg/kg的两性霉素B，直至总剂量达到1g，随后口服伊曲康唑400mg/天。急性期死亡率为19%，37.5%的患者复发。
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