Stollman Neil, Raskin Jeffrey B
Division of Gastroenterology, San Francisco General Hospital, and University of California San Francisco, San Francisco, CA 94110, USA.
Lancet. 2004 Feb 21;363(9409):631-9. doi: 10.1016/S0140-6736(04)15597-9.
Colonic diverticulosis refers to small outpouchings from the colonic lumen due to mucosal herniation through the colonic wall at sites of vascular perforation. Abnormal colonic motility and inadequate intake of dietary fibre have been implicated in its pathogenesis. This acquired abnormality is typically found in developed countries, and its prevalence rises with age. Most patients affected will remain entirely asymptomatic; however, 10-20% of those affected can manifest clinical syndromes, mainly diverticulitis and diverticular haemorrhage. As our elderly population grows, we can anticipate a concomitant rise in the number of patients with diverticular disease. Here, we review the incidence, pathophysiology, clinical presentation, and management of diverticular disease of the colon and its complications.
结肠憩室病是指由于黏膜通过结肠壁血管穿孔部位疝出而导致的从结肠腔向外的小袋状突出。结肠动力异常和膳食纤维摄入不足与该病的发病机制有关。这种后天性异常在发达国家较为常见,其患病率随年龄增长而上升。大多数受影响的患者完全没有症状;然而,10% - 20%的患者会出现临床综合征,主要是憩室炎和憩室出血。随着我国老年人口的增加,我们可以预期憩室病患者数量也会随之上升。在此,我们综述结肠憩室病及其并发症的发病率、病理生理学、临床表现和治疗。