James Andrew M, Smith Robin A J, Murphy Michael P
Medical Research Council Dunn Human Nutrition Unit, Cambridge, UK.
Arch Biochem Biophys. 2004 Mar 1;423(1):47-56. doi: 10.1016/j.abb.2003.12.025.
Coenzyme Q is both an essential electron carrier and an important antioxidant in the mitochondrial inner membrane. The reduced form, ubiquinol, decreases lipid peroxidation directly by acting as a chain breaking antioxidant and indirectly by recycling Vitamin E. The ubiquinone formed in preventing oxidative damage is reduced back to ubiquinol by the respiratory chain. As well as preventing lipid peroxidation, Coenzyme Q reacts with other reactive oxygen species, contributing to its effectiveness as an antioxidant. There is growing interest in using Coenzyme Q and related compounds therapeutically because mitochondrial oxidative damage contributes to degenerative diseases. Paradoxically, Coenzyme Q is also involved in superoxide production by the respiratory chain. To help understand how Coenzyme Q contributes to both mitochondrial oxidative damage and antioxidant defences, we have reviewed its antioxidant and prooxidant properties.
辅酶Q既是线粒体内膜中必不可少的电子载体，也是一种重要的抗氧化剂。还原形式的泛醇，通过作为链断裂抗氧化剂直接降低脂质过氧化，并通过循环利用维生素E间接降低脂质过氧化。在防止氧化损伤过程中形成的泛醌被呼吸链还原回泛醇。除了防止脂质过氧化外，辅酶Q还与其他活性氧反应，这有助于其作为抗氧化剂的有效性。由于线粒体氧化损伤与退行性疾病有关，因此人们对将辅酶Q及相关化合物用于治疗的兴趣日益浓厚。矛盾的是，辅酶Q也参与呼吸链产生超氧化物的过程。为了帮助理解辅酶Q如何导致线粒体氧化损伤并参与抗氧化防御，我们综述了其抗氧化和促氧化特性。
