四氧二氮杂冠醚衍生物作为毛细管电泳中手性选择剂修饰剂的应用。
Application of tetraoxadiaza-crown ether derivatives as chiral selector modifiers in capillary electrophoresis.
作者信息
Iványi Tímea, Pál Kornélia, Lázár István, Massart D Luc, Vander Heyden Yvan
机构信息
Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, H-4010 Debrecen, Hungary.
出版信息
J Chromatogr A. 2004 Mar 5;1028(2):325-32. doi: 10.1016/j.chroma.2003.11.097.
Two new diaza-crown ether derivatives (R-1, RS-1) have been synthesized from 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane and tested as potential chiral selectors in capillary electrophoresis (CE) for the chiral separation of five amino acid derivatives. The individual use of the selectors did not lead to chiral differentiation. However, they enhanced the enantioselective effect of different cyclodextrins in dual selector systems. In this paper, we report the effect of different substituted diaza-crown ether derivatives on the separation results obtained in dual systems with cyclodextrins.
已从1,4,10,13 - 四氧杂 - 7,16 - 二氮杂环十八烷合成了两种新型二氮杂冠醚衍生物（R - 1，RS - 1），并作为潜在的手性选择剂在毛细管电泳（CE）中用于五种氨基酸衍生物的手性分离测试。单独使用这些选择剂并未导致手性区分。然而，它们增强了双选择剂系统中不同环糊精的对映选择性效果。本文报道了不同取代的二氮杂冠醚衍生物对与环糊精的双系统中获得的分离结果的影响。
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