Koi Yumiko, Yamamoto Yuki, Fukunaga Saori, Kajitani Keiko, Ohara Masahiro, Daimaru Yutaka, Tahara Hidetoshi, Tamada Ryuichiro
Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan.
Department of Breast Surgery, Japan Agricultural Co-operatives Hiroshima General Hospital, Hatsukaichi, Hiroshima 738-8503, Japan.
Oncol Lett. 2023 Oct 31;26(6):535. doi: 10.3892/ol.2023.14123. eCollection 2023 Dec.
Oncocytic carcinoma of the breast is rare and its molecular profiles remain poorly understood. MicroRNAs (miRNAs/miRs) have been identified as contributors to carcinogenesis at the post-transcriptional level; thus, an aberrant expression of miRNAs has attracted attention as a potential biomarker of numerous diseases, including cancer. The present study reports the case of a 76-year-old woman diagnosed with oncocytic carcinoma of the breast. Considering the distinctive feature of oncocytic carcinoma of the breast, which is the presence of granular eosinophilic cytoplasm containing numerous mitochondria, the present study hypothesized that the expression of mitochondria-related miRNAs could be altered in oncocytic carcinomas. Aberrant expression levels of the miRNAs previously reported as mitochondria-related miRNAs, such as miR-221-3p, -146a-5p and -16-5p, were revealed in tissue from specimens of oncocytic carcinoma of the breast, compared with that of a more typical type of invasive ductal carcinoma of the breast. The present study highlights the changes in miRNA expression in oncocytic carcinoma of the breast, suggesting its potential as a biomarker for diagnosis.
乳腺嗜酸细胞癌较为罕见，其分子特征仍知之甚少。微小RNA（miRNA/miR）已被确定为转录后水平致癌作用的促成因素；因此，miRNA的异常表达作为包括癌症在内的多种疾病的潜在生物标志物已受到关注。本研究报告了一例76岁女性被诊断为乳腺嗜酸细胞癌的病例。考虑到乳腺嗜酸细胞癌的独特特征，即存在含有大量线粒体的颗粒状嗜酸性细胞质，本研究推测与线粒体相关的miRNA的表达在嗜酸细胞癌中可能会发生改变。与更典型的乳腺浸润性导管癌相比，在乳腺嗜酸细胞癌标本的组织中发现了先前报道的与线粒体相关的miRNA（如miR-221-3p、-146a-5p和-16-5p）的异常表达水平。本研究强调了乳腺嗜酸细胞癌中miRNA表达的变化，表明其作为诊断生物标志物的潜力。
