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Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.一种膜孕激素受体的克隆、表达与特性分析及证明其为鱼类卵母细胞减数分裂成熟过程中的中间体的证据
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2231-6. doi: 10.1073/pnas.0336132100. Epub 2003 Feb 6.
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Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors.雌激素诱导的pS2乳腺癌标志物基因受孤儿核受体ERR家族的转录调控。
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Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice.发育中的前列腺的雌激素印记是通过基质雌激素受体α介导的：αERKO和βERKO小鼠的研究
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Orphan nuclear receptors: from gene to function.孤儿核受体：从基因到功能
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Orphan nuclear receptors: shifting endocrinology into reverse.孤儿核受体：将内分泌学逆向转变
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Orphan nuclear receptors--new ligands and new possibilities.孤儿核受体——新配体与新机遇
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己烯雌酚可诱导鱼类卵母细胞成熟。

Diethylstilbestrol induces fish oocyte maturation.

作者信息

Tokumoto Toshinobu, Tokumoto Mika, Horiguchi Ryo, Ishikawa Katsutoshi, Nagahama Yoshitaka

机构信息

Department of Biology and Geosciences, Faculty of Science, Shizuoka University, Shizuoka 422-8529, Japan.

出版信息

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3686-90. doi: 10.1073/pnas.0400072101. Epub 2004 Feb 27.

DOI:10.1073/pnas.0400072101
PMID:14990787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC373523/
Abstract

An endocrine-disrupting chemical, diethylstilbestrol (DES), a nonsteroidal estrogen, triggers oocyte maturation in fish. The morphology (the time course of the change in germinal vesicle breakdown) and an intracellular molecular event (the de novo synthesis of cyclin B) induced by DES were indistinguishable from those induced by a natural maturation-inducing hormone, 17alpha,20beta-dihydroxy-4-pregnen-3-one (17,20beta-DHP). A synergistic action of DES on 17,20beta-DHP-induced oocyte maturation was observed. Both 17,20beta-DHP- and DES-induced oocyte maturation was inhibited by an antibody against the maturation-inducing hormone receptor. The structural requirement for the action of DES is discussed based on results obtained with DES analogs.

摘要

一种内分泌干扰化学物质，己烯雌酚（DES），一种非甾体雌激素，可触发鱼类卵母细胞成熟。DES诱导的形态变化（生发泡破裂变化的时间进程）和细胞内分子事件（细胞周期蛋白B的从头合成）与天然成熟诱导激素17α,20β-二羟基-4-孕烯-3-酮（17,20β-DHP）诱导的情况无法区分。观察到DES对17,20β-DHP诱导的卵母细胞成熟具有协同作用。抗成熟诱导激素受体的抗体可抑制17,20β-DHP和DES诱导的卵母细胞成熟。基于DES类似物的实验结果，讨论了DES作用的结构要求。