己烯雌酚可诱导鱼类卵母细胞成熟。
Diethylstilbestrol induces fish oocyte maturation.
作者信息
Tokumoto Toshinobu, Tokumoto Mika, Horiguchi Ryo, Ishikawa Katsutoshi, Nagahama Yoshitaka
机构信息
Department of Biology and Geosciences, Faculty of Science, Shizuoka University, Shizuoka 422-8529, Japan.
出版信息
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3686-90. doi: 10.1073/pnas.0400072101. Epub 2004 Feb 27.
Abstract
An endocrine-disrupting chemical, diethylstilbestrol (DES), a nonsteroidal estrogen, triggers oocyte maturation in fish. The morphology (the time course of the change in germinal vesicle breakdown) and an intracellular molecular event (the de novo synthesis of cyclin B) induced by DES were indistinguishable from those induced by a natural maturation-inducing hormone, 17alpha,20beta-dihydroxy-4-pregnen-3-one (17,20beta-DHP). A synergistic action of DES on 17,20beta-DHP-induced oocyte maturation was observed. Both 17,20beta-DHP- and DES-induced oocyte maturation was inhibited by an antibody against the maturation-inducing hormone receptor. The structural requirement for the action of DES is discussed based on results obtained with DES analogs.
摘要
一种内分泌干扰化学物质，己烯雌酚（DES），一种非甾体雌激素，可触发鱼类卵母细胞成熟。DES诱导的形态变化（生发泡破裂变化的时间进程）和细胞内分子事件（细胞周期蛋白B的从头合成）与天然成熟诱导激素17α,20β-二羟基-4-孕烯-3-酮（17,20β-DHP）诱导的情况无法区分。观察到DES对17,20β-DHP诱导的卵母细胞成熟具有协同作用。抗成熟诱导激素受体的抗体可抑制17,20β-DHP和DES诱导的卵母细胞成熟。基于DES类似物的实验结果，讨论了DES作用的结构要求。
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