Magriñà J, Bosch X, Garcia A, Pons F, Moragas M, Roig E, Navarro Lopez F, Setoain J
Cardiology Service, University of Barcelona, Spain.
Clin Cardiol. 1992 Jul;15(7):497-503. doi: 10.1002/clc.4960150706.
To assess the diagnostic value of technetium-99m-MIBI (99mTc-MIBI) as a myocardial perfusion imaging agent, and if rest and exercise scans could be performed on the same day, 21 patients with coronary artery disease were studied. Qualitative planar 201-thallium (201Tl) scans, coronary angiography, or both were also performed (median between studies 11 days). In 10 patients an injection of 740 mBq of 99mTc-MIBI at stress was followed by a second injection of 740 mBq at rest 24 h later (long interal) (LI). In 11 patients injection of 370 mBq at rest was followed 3 h later by an injection of 740 mBq at stress (short interval) (SI). Exercise scans were performed to similar maximal work load (LI = 6.6 +/- 1.8 METs; SI = 6.3 +/- 1.7 METs; 201Tl = 6.8 +/- 1.2 METs; p = NS) and double product (LI = 19551 +/- 7370; SI = 19900 +/- 6797; 201Tl = 19965 +/- 5282; p = NS). Overall, 99mTc-MIBI and 201Tl agreed in 92% of the patients tested and in 165 of 180 (92%) left ventricular segments in both 99mTc-MIBI protocols using short and long intervals between injections. In 15 patients with significant stenosis, 99mTc-MIBI correctly identified 13 patients (sensitivity of 87%). Thus, 99mTc-MIBI is a useful imaging agent with similar diagnostic value as 201Tl. In spite of its lack of myocardial redistribution, 99mTc-MIBI rest and exercise scans performed on the same day seem to have a similar concordance rate with 201Tl as when performed on separate days.
为评估锝-99m-甲氧基异丁基异腈（99mTc-MIBI）作为心肌灌注显像剂的诊断价值，以及静息和运动扫描是否可在同一天进行，对21例冠心病患者进行了研究。还进行了定性平面201铊（201Tl）扫描、冠状动脉造影或两者同时进行（研究之间的中位数为11天）。10例患者在运动时注射740mBq的99mTc-MIBI，24小时后在静息时再次注射740mBq（长间隔）（LI）。11例患者在静息时注射370mBq，3小时后在运动时注射740mBq（短间隔）（SI）。运动扫描的最大工作量相似（LI = 6.6 +/- 1.8代谢当量；SI = 6.3 +/- 1.7代谢当量；201Tl = 6.8 +/- 1.2代谢当量；p = 无显著性差异）和双乘积（LI = 19551 +/- 7370；SI = 19900 +/- 6797；201Tl = 19965 +/- 5282；p = 无显著性差异）。总体而言，在使用短间隔和长间隔注射的两种99mTc-MIBI方案中，99mTc-MIBI与201Tl在92%的受试患者以及180个左心室节段中的165个（92%）中结果一致。在15例有明显狭窄的患者中，99mTc-MIBI正确识别出13例患者（敏感性为87%）。因此，99mTc-MIBI是一种有用的显像剂，其诊断价值与201Tl相似。尽管99mTc-MIBI缺乏心肌再分布，但同一天进行的99mTc-MIBI静息和运动扫描与201Tl的符合率似乎与分不同天进行时相似。
