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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Leite L C, Furtado M F, Correa T C, Raw I

Biotechnology Center, Instituto Butantan, São Paulo, Brazil.

Comp Biochem Physiol B. 1992 Jul;102(3):515-20. doi: 10.1016/0305-0491(92)90042-p.

The elution profiles and the caseinolytic, myotoxic, coagulant and hemorrhagic activities of the venoms of seven Bothrops species fractionated on a Mono-Q FPLC column were analyzed. 2. Each venom separated into 16-20 peaks, with good reproducibility and the activities were concentrated in virtually discrete regions of the chromatogram. 3. There is a considerable overlap of active proteins in the different species venoms and our results indicate that a venom pool with the species B. jararaca, B. jararacussu, B. moojeni, B. neuwiedi and B. atrox venoms would contain the major active proteins determined in the seven species.

分析了在Mono-Q FPLC柱上分离的七种矛头蝮属物种毒液的洗脱曲线以及酪蛋白溶解、肌毒性、凝血和出血活性。2. 每种毒液分离成16 - 20个峰，具有良好的重现性，且活性集中在色谱图几乎不连续的区域。3. 不同物种毒液中的活性蛋白有相当大的重叠，我们的结果表明，含有南美矛头蝮、巴西矛头蝮、穆氏矛头蝮、纳氏矛头蝮和矛头蝮毒液的毒液库将包含在这七个物种中确定的主要活性蛋白。

Leite L C, Furtado M F, Correa T C, Raw I

Biotechnology Center, Instituto Butantan, São Paulo, Brazil.

Comp Biochem Physiol B. 1992 Jul;102(3):515-20. doi: 10.1016/0305-0491(92)90042-p.

The elution profiles and the caseinolytic, myotoxic, coagulant and hemorrhagic activities of the venoms of seven Bothrops species fractionated on a Mono-Q FPLC column were analyzed. 2. Each venom separated into 16-20 peaks, with good reproducibility and the activities were concentrated in virtually discrete regions of the chromatogram. 3. There is a considerable overlap of active proteins in the different species venoms and our results indicate that a venom pool with the species B. jararaca, B. jararacussu, B. moojeni, B. neuwiedi and B. atrox venoms would contain the major active proteins determined in the seven species.

分析了在Mono-Q FPLC柱上分离的七种矛头蝮属物种毒液的洗脱曲线以及酪蛋白溶解、肌毒性、凝血和出血活性。2. 每种毒液分离成16 - 20个峰，具有良好的重现性，且活性集中在色谱图几乎不连续的区域。3. 不同物种毒液中的活性蛋白有相当大的重叠，我们的结果表明，含有南美矛头蝮、巴西矛头蝮、穆氏矛头蝮、纳氏矛头蝮和矛头蝮毒液的毒液库将包含在这七个物种中确定的主要活性蛋白。