Dwork Andrew J, Arango Victoria, Underwood Mark, Ilievski Boro, Rosoklija Gorazd, Sackeim Harold A, Lisanby Sarah H
Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA.
Am J Psychiatry. 2004 Mar;161(3):576-8. doi: 10.1176/appi.ajp.161.3.576.
The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge.
Twelve Macaca mullata received 6 weeks of daily ECT, magnetic seizure therapy, or anesthesia alone. After perfusion fixation, their brains were examined while masked to intervention.
No identified lesions were attributable to the interventions. Cortical and hippocampal immunoreactivity for glial fibrillary acidic protein (an astrocytic marker) was most intense in the group that received ECT.
This small but rigorous primate study supports the view that ECT does not produce histological lesions in the brain and provides the first comparable safety data on magnetic seizure therapy.
据作者所知，本文呈现了首例使用灌注固定法及充分对照的非人灵长类动物电休克治疗（ECT）神经病理学研究的初步结果，也是首例将ECT与磁惊厥治疗进行比较的研究。
12只恒河猴分别接受为期6周的每日ECT、磁惊厥治疗或仅接受麻醉。在灌注固定后，对其大脑进行检查，检查时对干预措施保密。
未发现可归因于这些干预措施的病变。接受ECT的组中，胶质纤维酸性蛋白（一种星形胶质细胞标志物）的皮质和海马免疫反应性最强。
这项规模虽小但严谨的灵长类动物研究支持以下观点，即ECT不会在大脑中产生组织学病变，并提供了关于磁惊厥治疗的首批可比安全性数据。
