Liu G T, Qian Y Z, Zhang P, Dong W H, Qi Y M, Guo H T
Department of Pathophysiology, Henan Medical University, Zhengzhou.
Chin Med J (Engl). 1992 May;105(5):394-400.
In this paper, the mutagenicity and carcinogenicity of alternariol monomethyl ether (AME), alternariol (AOH), and their relevance to the etiology of human esophageal cancer were studied. These mycotoxins were produced by Alternaria alternata which was the main contaminating fungi isolated from the grain in Linxian County, an area with high incidence of esophageal cancer. This study demonstrated that: 1. AME and AOH might cause cell mutagenicity and transformation; 2. AME and AOH could combine with the DNA isolated from human fetal esophageal epithelium, activate the oncogens, c-H-ras and c-mys in it, and promote proliferation of human fetal esophageal epithelium in vitro; 3. squamous cell carcinoma of the fetal esophagus could be induced by AOH. According to the results of the studies of AME and AOH mentioned above, we consider that Alternaria alternata plays an important role in the etiology of human esophageal cancer.
本文研究了单端孢霉烯族毒素单甲醚（AME）、交链孢酚（AOH）的致突变性、致癌性及其与人类食管癌病因的相关性。这些霉菌毒素由链格孢菌产生，链格孢菌是从食管癌高发地区林县的粮食中分离出的主要污染真菌。本研究表明：1. AME和AOH可能引起细胞致突变性和转化；2. AME和AOH可与人胎儿食管上皮细胞分离的DNA结合，激活其中的癌基因c-H-ras和c-mys，并促进人胎儿食管上皮细胞在体外增殖；3. AOH可诱导胎儿食管鳞状细胞癌。根据上述对AME和AOH的研究结果，我们认为链格孢菌在人类食管癌病因中起重要作用。
