Wu Pei-Lin, Lin Fu-Wen, Wu Tian-Shung, Kuoh Chang-Sheng, Lee Kuo-Hsiung, Lee Shiow-Ju
Department of Chemistry, National Cheng Kung University, Taiwan.
Chem Pharm Bull (Tokyo). 2004 Mar;52(3):345-9. doi: 10.1248/cpb.52.345.
Three new compounds: begonanline (1). nantoamide (2). and methyl (S)-glycerate (3). as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4). dihydrocucurbitacin B (5). cucurbitacin E (6). dihydrocucurbitacin E (7). cucurbitacin I (8). and (-)-auranamide (9). showed cytotoxicity against four human cancer cell lines. 3beta,22alpha-Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.
南投秋海棠碱（1）、南投酰胺（2）和（S）-甘油酸甲酯（3），以及44种已知化合物。这些化合物的结构通过光谱分析和/或X射线晶体学确定。其中，葫芦素B（4）、二氢葫芦素B（5）、葫芦素E（6）、二氢葫芦素E（7）、葫芦素I（8）和（-）-金合欢酰胺（9）对四种人类癌细胞系显示出细胞毒性。3β，22α-二羟基齐墩果-12-烯-29-酸（10）、吲哚-3-羧酸（11）、5,7-二羟基色酮（12）和（-）-儿茶素（13）在H9淋巴细胞中对HIV复制表现出显著活性。
