Uter Wolfgang, Lessmann Holger, Geier Johannes, Schnuch Axel
Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nürnberg, Erlangen, Germany.
Contact Dermatitis. 2003 Nov;49(5):236-40. doi: 10.1111/j.0105-1873.2003.0233.x.
Not only hairdressers, but also their clients or home-users of hair cosmetic products may become sensitized to one of the product constituents. The present analysis addresses the question whether the pattern of sensitization is different in these 2 groups and includes female patients who consulted with the participating centres of the IVDK (http://www.ivdk.org) between 1995 and 2002, and in whom hair cosmetics have been considered as being causative of their contact dermatitis. Among these, 2 subgroups were identified: (i) patients, currently or previously working as hairdressers, diagnosed with occupational skin disease (H, n = 884) and (ii) patients who never worked as hairdressers, i.e. clients (C, n = 1217). Previous atopic eczema was twice as common among H, who were also much younger (median age 24 versus 46 in C). Analysis of sensitization frequencies and patterns showed the well-known decline of contact allergy to glyceryl monothioglycolate (GMTG) in H from 31.2% to 8.5%. Among the C, 1.7% were allergic to GMTG. Concerning p-phenylenediamine, a steady decline from 27.6% to 17.2% was observed in H, while no trend was found in C (12.6% and 16.6% in the first and the last 2-year period, respectively). Conversely, a very slight decline of p-toluenediamine sensitization was observed in H (from 29.5% to 24.8%), while at the same time a significant increase was noted in C (from 8.7% to 16.7%). A slighter increase was also noted with ammonium persulfate in C (3.1-6.8%), while the proportion of H sensitized remained largely constant at about 26%.
不仅美发师,其客户或头发化妆品的家庭使用者也可能对产品中的某种成分过敏。本分析探讨了这两组人群的过敏模式是否存在差异,研究对象包括1995年至2002年间在IVDK(http://www.ivdk.org)参与中心咨询过的女性患者,她们的接触性皮炎被认为是由头发化妆品引起的。在这些患者中,确定了两个亚组:(i)目前或以前从事美发师工作且被诊断患有职业性皮肤病的患者(H组,n = 884);(ii)从未从事过美发师工作的患者,即客户(C组,n = 1217)。既往特应性湿疹在H组中的发生率是C组的两倍,H组患者也更年轻(中位年龄24岁,而C组为46岁)。过敏频率和模式分析显示,H组中对巯基乙酸甘油酯(GMTG)的接触性过敏明显下降,从31.2%降至8.5%。在C组中,1.7%的人对GMTG过敏。关于对苯二胺,H组从27.6%稳步下降至17.2%,而C组未发现明显趋势(在第一个和最后一个两年期分别为12.6%和16.6%)。相反,H组对甲苯二胺的过敏略有下降(从29.5%降至24.8%),而C组同时出现显著上升(从8.7%升至16.7%)。C组中过硫酸铵的过敏率也略有上升(从3.1%至6.8%),而H组的过敏比例基本保持在26%左右。