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植物分子农场:系统与产品

Plant molecular farming: systems and products.

作者信息

Horn M E, Woodard S L, Howard J A

机构信息

ProdiGene, 101 Gateway Blvd. Suite 100, College Station, TX 77845, USA.

出版信息

Plant Cell Rep. 2004 May;22(10):711-20. doi: 10.1007/s00299-004-0767-1. Epub 2004 Feb 28.

DOI:10.1007/s00299-004-0767-1
PMID:14997337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7079917/
Abstract

Plant molecular farming is a new and promising industry involving plant biotechnology. In this review, we describe several diverse plant systems that have been developed to produce commercially useful proteins for pharmaceutical and industrial uses. The advantages and disadvantages of each system are discussed. The first plant-derived molecular farming products have reached the marketplace and other products are poised to join them during the next few years. We explain the rationale for using plants as biofactories. We also describe the products currently on the market, and those that appear likely to join them in the near future. Lastly, we discuss the issue of public acceptance of molecular farming products.

摘要

植物分子农业是一个涉及植物生物技术的新兴且有前景的产业。在本综述中,我们描述了几种不同的植物系统,这些系统已被开发用于生产用于制药和工业用途的具有商业价值的蛋白质。讨论了每个系统的优缺点。首批植物源分子农业产品已进入市场,其他产品也准备在未来几年加入它们的行列。我们解释了将植物用作生物工厂的基本原理。我们还描述了目前市场上的产品,以及那些可能在不久的将来加入它们的产品。最后,我们讨论了公众对分子农业产品的接受问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df92/7079917/20ef9d2b9a0b/s00299-004-0767-1fhb1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df92/7079917/20ef9d2b9a0b/s00299-004-0767-1fhb1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df92/7079917/20ef9d2b9a0b/s00299-004-0767-1fhb1.jpg

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本文引用的文献

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Inheritance of functional foreign genes in plants.植物中外源基因的功能遗传。
Science. 1984 Feb 3;223(4635):496-8. doi: 10.1126/science.223.4635.496.
2
Advantageous features of plant-based systems for the development of HIV vaccines.用于开发HIV疫苗的植物源系统的优势特性。
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A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine.一种用于动物疫苗的玉米基递送系统:一种口服传染性胃肠炎病毒疫苗可增强猪的泌乳免疫。
与白细胞介素-15受体α-白细胞介素-15复合物结合的植物源派姆单抗显示出有效的抗肿瘤活性。
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Duckweeds as edible vaccines in the animal farming industry.浮萍作为动物养殖业中的可食用疫苗。
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Molecular Farming of Pembrolizumab and Nivolumab.泊洛妥珠单抗和纳武利尤单抗的分子农业生产。
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Plant-derived PAP proteins fused to immunoglobulin A and M Fc domains induce anti-prostate cancer immune response in mice.植物来源的 PAP 蛋白与免疫球蛋白 A 和 M Fc 结构域融合,可在小鼠中诱导抗前列腺癌免疫反应。
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Plants (Basel). 2022 Dec 8;11(24):3425. doi: 10.3390/plants11243425.
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Transgenic Res. 2022 Oct;31(4-5):567-578. doi: 10.1007/s11248-022-00320-y. Epub 2022 Aug 17.
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Plant-Based Vaccines in Combat against Coronavirus Diseases.对抗冠状病毒疾病的植物源疫苗
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Vaccine. 2004 Jun 23;22(19):2420-4. doi: 10.1016/j.vaccine.2003.11.066.
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