[胃机械感受器受刺激时分泌反应的衰老相关特征]
[Aging-related characteristics of the secretory response of the stomach to stimulation of its mechanoreceptors].
作者信息
Korkushko O B, Hrihorov Iu H, Dzizins'ka O O
出版信息
Fiziol Zh (1978). 1992 May-Jun;38(3):53-9.
Age peculiarities of the gastric secretory response to the mechanical stimulation have been studied in thirty-one healthy subjects aged 60-79 and ten healthy subjects aged 20-35 (a control group). The secretory response of the gastric glands to mechanical distention of the stomach with 600 ml of water is found to decrease with aging. No changes in gastrin concentration in plasma during balloon distention have been revealed, so this confirms the hypothesis that stimulation of acid secretion by distention is mediated by reflexes without participation of the gastrin mechanism. Distention of the stomach with 800 ml of water induces significant inhibition of the acid output in subjects aged over 60. The mechanism of this reaction is not clear yet and needs further investigation.
对31名60 - 79岁的健康受试者和10名20 - 35岁的健康受试者（对照组）研究了胃对机械刺激的分泌反应的年龄特点。发现胃腺对用600毫升水进行胃机械扩张的分泌反应随年龄增长而降低。在气囊扩张期间未发现血浆胃泌素浓度有变化，因此这证实了以下假设，即扩张引起的胃酸分泌刺激是由反射介导的，而胃泌素机制不参与其中。用800毫升水扩张胃会导致60岁以上受试者的胃酸分泌显著抑制。这种反应的机制尚不清楚，需要进一步研究。
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