Díaz-Aparicio E, Hernández L, Suárez-Güemes F
CENID Microbiología, Instituto Nacional de Investigaciones Agrícolas, Forestales y Pecuarias, Carretera Federal México-Toluca Km. 15.5, Cuajimalpa, Mexico.
Trop Anim Health Prod. 2004 Feb;36(2):117-21. doi: 10.1023/b:trop.0000012106.84833.3b.
The protection conferred by the reduced-dose Rev 1 Brucella melitensis vaccine in goats that had been immunized 5 years previously was evaluated. Sixteen goats vaccinated 5 years before with Rev 1 (1 x 10(5) cfu) and 5 non-vaccinated goats were challenged with B. melitensis 16M (4 x 10(5) cfu) using the conjunctival route. After giving birth or aborting, the goats were sacrificed and tissue samples were taken for bacteriological study. The challenge strain was recovered in 12%, of the animals from the vaccinated group, and in (80% of the control group. It is concluded, therefore that the use of reduced-dose Rev 1 protects goats vaccinated in endemic areas for at least 5 years after immunization.
对5年前接种过减毒Rev 1型羊布鲁氏菌疫苗的山羊所获得的保护作用进行了评估。16只5年前接种过Rev 1（1×10⁵cfu）的山羊和5只未接种疫苗的山羊通过结膜途径用羊布鲁氏菌16M（4×10⁵cfu）进行攻毒。在分娩或流产后，将山羊处死并采集组织样本进行细菌学研究。攻毒菌株在接种疫苗组12%的动物中检出，而在对照组中为80%。因此得出结论，使用减毒Rev 1疫苗可保护在流行地区接种过疫苗的山羊在免疫后至少5年内不受感染。
