Koutoubi Samer, Huffman Fatma G
Nutrition Department, Bastyr University, Kenmore, Washington 98028, USA.
Ethn Dis. 2004 Winter;14(1):64-72.
The main objective of our study was to determine and compare total serum homocysteine (tHcy) levels among tri-ethnic college students. The 180 tri-ethnic subjects completed Cardiovascular Risk Assessment questionnaires, and gave 15 mL fasting blood for serum tHcy and blood lipid analysis. The mean tHcy (+/- SD) of the all subjects was 6.33 +/- 3.15 micromol/L. Male subjects had significantly (P=.001) higher serum tHcy levels compared with female subjects. Black non-Hispanic females and Hispanic females showed significantly (P=.003) lower tHcy levels than White non-Hispanic females. Moderate elevations of tHcy levels were strongly related to cigarette smoking, physical inactivity, behavioral style, high blood pressure, and low intakes of folate, and vitamins B6 and B12. A positive association of tHcy levels with cardiovascular heart disease (CHD) risk point standards was observed in females (P=.001), Hispanic (P=.001), Hispanic males (P=.049), Hispanic females (P=.009), and Black non-Hispanic females (P=.005). We observed gender and ethnic differences in tHcy levels of this young population with normal tHcy levels. Abnormally high tHcy concentrations appear to be acquired later in life.
我们研究的主要目的是测定并比较三个不同种族的大学生血清总同型半胱氨酸（tHcy）水平。180名来自三个不同种族的受试者完成了心血管风险评估问卷，并提供了15毫升空腹血样用于血清tHcy和血脂分析。所有受试者的平均tHcy（±标准差）为6.33±3.15微摩尔/升。男性受试者的血清tHcy水平显著高于女性受试者（P = 0.001）。非西班牙裔黑人女性和西班牙裔女性的tHcy水平显著低于非西班牙裔白人女性（P = 0.003）。tHcy水平的中度升高与吸烟、缺乏运动、行为方式、高血压以及叶酸、维生素B6和维生素B12的低摄入量密切相关。在女性（P = 0.001）、西班牙裔（P = 0.001）、西班牙裔男性（P = 0.049）、西班牙裔女性（P = 0.009）和非西班牙裔黑人女性（P = 0.005）中，观察到tHcy水平与心血管疾病（CHD）风险点标准呈正相关。我们在tHcy水平正常的年轻人群中观察到了tHcy水平的性别和种族差异。异常高的tHcy浓度似乎是在生命后期获得的。
