Searle Philip A, Glass Keithney A, Hochlowski Jill E
Medicinal Chemistry Technologies, Global Pharmaceutical Research & Development, Abbott Laboratories, Department R4CP, Building AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA.
J Comb Chem. 2004 Mar-Apr;6(2):175-80. doi: 10.1021/cc0340372.
A diverse set of 16 high-throughput organic synthesis libraries, consisting of 48 samples per library, has been purified by both preparative supercritical fluid chromatography (SFC) and preparative high-performance liquid chromatography (HPLC). This paper details the relative effectiveness of these two purification techniques in terms of success, yield, and purity of final product.
一组多样的16个高通量有机合成文库，每个文库包含48个样品，已通过制备型超临界流体色谱（SFC）和制备型高效液相色谱（HPLC）进行了纯化。本文详细介绍了这两种纯化技术在最终产物的成功率、产率和纯度方面的相对有效性。
