制备型高效液相色谱/质谱联用技术与制备型超临界流体色谱技术用于化合物库高通量纯化的比较。
Comparison of preparative HPLC/MS and preparative SFC techniques for the high-throughput purification of compound libraries.
作者信息
Searle Philip A, Glass Keithney A, Hochlowski Jill E
机构信息
Medicinal Chemistry Technologies, Global Pharmaceutical Research & Development, Abbott Laboratories, Department R4CP, Building AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA.
出版信息
J Comb Chem. 2004 Mar-Apr;6(2):175-80. doi: 10.1021/cc0340372.
A diverse set of 16 high-throughput organic synthesis libraries, consisting of 48 samples per library, has been purified by both preparative supercritical fluid chromatography (SFC) and preparative high-performance liquid chromatography (HPLC). This paper details the relative effectiveness of these two purification techniques in terms of success, yield, and purity of final product.
一组多样的16个高通量有机合成文库，每个文库包含48个样品，已通过制备型超临界流体色谱（SFC）和制备型高效液相色谱（HPLC）进行了纯化。本文详细介绍了这两种纯化技术在最终产物的成功率、产率和纯度方面的相对有效性。
Zotero 插件