Wetherell Julie Loebach, Thorp Steven R, Patterson Thomas L, Golshan Shahrokh, Jeste Dilip V, Gatz Margaret
Department of Psychiatry, University of California, San Diego and Veterans Affairs San Diego Healthcase System, 9500 Gilman Drive, Dept. 0603V, La Jolla, CA 92093-0603, USA.
J Psychiatr Res. 2004 May-Jun;38(3):305-12. doi: 10.1016/j.jpsychires.2003.09.003.
To examine the impact of late-life generalized anxiety disorder (GAD) on health-related quality of life.
We compared quality of life in 75 treatment-seeking older adults with GAD, 39 of whom had psychiatric comorbidity, with 32 older adults without psychiatric illness. We examined predictors of quality of life in these samples. We also compared data from the GAD patients to published norms from a large national sample of older adults with chronic medical conditions or major depression.
Older GAD patients reported worse health-related quality of life across most domains than asymptomatic older individuals. There were no differences in quality of life between GAD patients with and without psychiatric comorbidity, and comorbidity did not predict quality of life in multivariate regression analyses. Presence of GAD or symptoms of anxiety or depression were significantly related to impairment in every domain of quality of life. Comparisons with national norms suggest that older GAD patients report overall worse quality of life than individuals with recent acute myocardial infarction or type II diabetes, and are comparable in quality of life to individuals with major depression.
Results suggest that late-life GAD is associated with substantial impairment in quality of life, and these findings cannot be explained by psychiatric comorbidity.
探讨老年期广泛性焦虑障碍（GAD）对健康相关生活质量的影响。
我们将75名寻求治疗的患有GAD的老年人（其中39人患有精神疾病合并症）的生活质量与32名无精神疾病的老年人进行了比较。我们研究了这些样本中生活质量的预测因素。我们还将GAD患者的数据与来自一个大型全国性样本（患有慢性疾病或重度抑郁症的老年人）的已发表标准进行了比较。
与无症状的老年人相比，老年GAD患者在大多数领域的健康相关生活质量更差。有精神疾病合并症和无精神疾病合并症的GAD患者在生活质量上没有差异，并且在多变量回归分析中合并症不能预测生活质量。GAD的存在或焦虑或抑郁症状与生活质量的各个领域的损害显著相关。与全国标准的比较表明，老年GAD患者报告的总体生活质量比近期急性心肌梗死或II型糖尿病患者更差，并且在生活质量上与重度抑郁症患者相当。
结果表明，老年期GAD与生活质量的严重损害有关，并且这些发现不能用精神疾病合并症来解释。
