Quinn Joseph F, Montine Kathleen S, Moore Milar, Morrow Jason D, Kaye Jeffrey A, Montine Thomas J
Department Neurology, Oregon Health and Sciences University, Portland, OR, USA.
J Alzheimers Dis. 2004 Feb;6(1):93-7. doi: 10.3233/jad-2004-6110.
We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both alpha-tocopherol and vitamin C.
我们报告了对轻度阿尔茨海默病（AD）患者脑脊液（CSF）F2-异前列腺素（IsoPs）的首次纵向分析，F2-异前列腺素是脂质过氧化的定量体内生物标志物。脑脊液F2-异前列腺素：（i）在随访一年以上的患者中显著升高；（ii）在校正脑室扩大的变化后，与痴呆的一些临床指标相关；（iii）在同时使用α-生育酚和维生素C的患者中显著降低。
