[模拟失重对大鼠比目鱼肌肌梭神经末梢形态的影响]
[Influence of simulated weightlessness on the morphology of nerve endings of muscle spindle in rat soleus muscle].
作者信息
Tang Bin, Fan Xiao-li, Wu Su-di, Li Ming
机构信息
Department of Physiology, Xi'an Jiaotong University, Xi'an, China.
出版信息
Space Med Med Eng (Beijing). 2003 Jun;16(3):162-4.
OBJECTIVE
To study changes in structure and innervation of soleus muscle spindle in rats induced by simulated weightlessness.
METHOD
Weightlessness was simulated by tail suspension in female rats. The technique of Fawosky's Staining was used to detect the morphology of nerve endings of soleus muscle spindle in 7 d, 14 d, 21 d tail-suspended and control rats.
RESULT
The intrafusal muscle fibers were regular and nerve endings were intact and clear in the soleus spindles of control rats. No obvious change was observed in muscle spindles of 7 d tail-suspended rats. Intrafusal muscle fibers became irregular, with rough and vague nerve endings in 14 d tail-suspended rats. The distinct retrograde change of muscle spindles and nerve endings were observed in 21 d tail-suspended rats. Degeneration and rupture were found in nerve endings, which made it unclear and pale in staining.
CONCLUSION
Simulated weightlessness could induce time-related changes in structure and innervation of soleus muscle spindle in rats.
目的
研究模拟失重诱导大鼠比目鱼肌肌梭结构及神经支配的变化。
方法
采用尾悬吊法模拟雌性大鼠失重状态。运用Fawosky染色技术检测7天、14天、21天尾悬吊大鼠及对照大鼠比目鱼肌肌梭神经末梢的形态。
结果
对照大鼠比目鱼肌肌梭内肌纤维规则，神经末梢完整清晰。7天尾悬吊大鼠的肌梭未见明显变化。14天尾悬吊大鼠的梭内肌纤维变得不规则，神经末梢粗糙模糊。21天尾悬吊大鼠的肌梭和神经末梢出现明显的逆行性改变。神经末梢发生变性和断裂，染色不清且变淡。
结论
模拟失重可诱导大鼠比目鱼肌肌梭结构及神经支配随时间发生变化。
Zotero 插件