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FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells.
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Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
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FHIT as tumor suppressor: mechanisms and therapeutic opportunities.
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Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.
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Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.
Biochemistry. 2005 Apr 26;44(16):6286-92. doi: 10.1021/bi047670s.
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Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines.
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Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit.
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Integrated analysis of gene alterations in cancer.
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The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit.
Cells. 2023 Jan 17;12(3):353. doi: 10.3390/cells12030353.
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Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor ApA Elucidates Its Inhibitory Action on Translation.
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Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response.
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Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ.
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Comprehensive characterization of the genomic alterations in human gastric cancer.
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Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.
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Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
PLoS One. 2013 Nov 6;8(11):e78610. doi: 10.1371/journal.pone.0078610. eCollection 2013.
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Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.
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Multiple Patterns of FHIT Gene Homozygous Deletion in Egyptian Breast Cancer Patients.
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Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14988-93. doi: 10.1073/pnas.2336256100. Epub 2003 Nov 20.
2
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1592-7. doi: 10.1073/pnas.0437915100. Epub 2003 Feb 6.
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Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation.
Blood. 2003 Jan 15;101(2):585-93. doi: 10.1182/blood-2002-06-1779. Epub 2002 Aug 29.
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Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2.
Br J Cancer. 2002 Feb 1;86(3):463-9. doi: 10.1038/sj.bjc.6600080.
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The tumor spectrum in FHIT-deficient mice.
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10250-5. doi: 10.1073/pnas.191345898. Epub 2001 Aug 21.
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Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.
Cancer Res. 2001 Jun 15;61(12):4827-36.
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Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.
Cancer Res. 2001 Feb 15;61(4):1578-84.
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Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.
Biochem J. 2000 Dec 1;352 Pt 2(Pt 2):443-8.
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Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.
J Cell Biol. 2000 Sep 4;150(5):1037-56. doi: 10.1083/jcb.150.5.1037.
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Regulation of both apoptosis and cell survival by the v-Src oncoprotein.
Cell Death Differ. 2000 Aug;7(8):685-96. doi: 10.1038/sj.cdd.4400700.
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