与奎宁治疗疟疾相关的靶心状黄斑病变。
Bull's-eye maculopathy associated with quinacrine therapy for malaria.
作者信息
Browning David J
机构信息
Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina 28210, USA.
出版信息
Am J Ophthalmol. 2004 Mar;137(3):577-9. doi: 10.1016/j.ajo.2003.08.047.
PURPOSE
To report a side effect of quinacrine therapy for malaria.
DESIGN
Case report.
METHODS
Review of clinical chart and photographs.
SETTING
Private retina practice.
RESULTS
A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.
CONCLUSIONS
Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
目的
报告奎纳克林治疗疟疾的一种副作用。
设计
病例报告。
方法
回顾临床病历及照片。
地点
私人视网膜诊所。
结果
一名患者在服用奎纳克林18个月预防疟疾45年后，出现双侧对称的靶心样黄斑病变。在15年的随访中记录了临床症状的进展。临床表现与氯喹和羟氯喹黄斑病变相同。
结论
用于预防疟疾的低剂量奎纳克林可能会在某些患者中导致延迟出现的严重黄斑病变，与氯喹黄斑病变难以区分。
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